ETF comparison
FHLC vs XBI
Both Healthcare.
Fidelity MSCI Health Care Index ETF · State Street SPDR S&P Biotech ETF
Holdings overlap
119 positions appear in both funds. Buying equal dollars of FHLC and XBI would leave roughly 13.4% of each dollar exposed to the same underlying securities.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
FHLC is 27 bps cheaper than XBI. On a $100,000 position that's about $266/yr more in fees for XBI.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with FHLC vs XBI.
Top shared holdings
119 shared in total| # | Holding | In FHLC | In XBI | Overlap |
|---|---|---|---|---|
| 1 | Regeneron Pharmaceuticals Inc | 1.18% | 1.14% | 1.14% |
| 2 | AbbVie Inc | 6.03% | 1.09% | 1.09% |
| 3 | Gilead Sciences Inc | 2.62% | 1.09% | 1.09% |
| 4 | Amgen Inc | 3.01% | 1.06% | 1.06% |
| 5 | Vertex Pharmaceuticals Inc | 1.75% | 1.03% | 1.03% |
| 6 | Alnylam Pharmaceuticals Inc | 0.66% | 1.18% | 0.66% |
| 7 | Insmed Inc | 0.47% | 1.34% | 0.47% |
| 8 | Biogen Inc | 0.45% | 1.10% | 0.45% |
| 9 | Natera Inc | 0.44% | 1.16% | 0.44% |
| 10 | United Therapeutics Corp | 0.38% | 1.24% | 0.38% |
| 11 | Revolution Medicines Inc | 0.38% | 1.11% | 0.38% |
| 12 | Moderna Inc | 0.26% | 1.03% | 0.26% |
Only in FHLC
219 total- Eli Lilly & Co 12.13%
- Johnson & Johnson 8.94%
- UnitedHealth Group Inc 5.42%
- Merck & Co Inc 4.38%
- Thermo Fisher Scientific Inc 2.91%
- Intuitive Surgical Inc 2.62%
- Abbott Laboratories 2.55%
- Pfizer Inc 2.45%
- Bristol-Myers Squibb Co 1.99%
- Danaher Corp 1.84%
Only in XBI
35 total- Summit Therapeutics Inc 1.24%
- Amicus Therapeutics Inc 1.15%
- Arcellx Inc 1.14%
- Corvus Pharmaceuticals Inc 0.42%
- Day One Biopharmaceuticals Inc 0.32%
- SELLAS Life Sciences Group Inc 0.27%
- Rigel Pharmaceuticals Inc 0.26%
- Replimune Group Inc 0.23%
- Sionna Therapeutics Inc 0.22%
- Vor BioPharma Inc 0.22%
Open FHLC or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.