ETF comparison
XBI vs XLV
Both Healthcare.
State Street SPDR S&P Biotech ETF · State Street Health Care Select Sector SPDR ETF
Holdings overlap
8 positions appear in both funds. Buying equal dollars of XBI and XLV would leave roughly 6.3% of each dollar exposed to the same underlying securities.
Unmatched is the part of a fund's weight the other fund doesn't match: names only it holds, plus any extra weight it puts in names both funds hold.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
XLV is 27 bps cheaper than XBI. On a $100,000 position that's about $270/yr more in fees for XBI.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with XBI vs XLV.
Top shared holdings
8 shared in total| # | Holding | In XBI | In XLV | Overlap |
|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals Inc | 1.06% | 2.19% | 1.06% |
| 2 | AbbVie Inc | 1.04% | 7.74% | 1.04% |
| 3 | Amgen Inc | 0.99% | 3.40% | 0.99% |
| 4 | Gilead Sciences Inc | 0.96% | 2.73% | 0.96% |
| 5 | Regeneron Pharmaceuticals Inc | 0.96% | 1.08% | 0.96% |
| 6 | Biogen Inc | 1.03% | 0.56% | 0.56% |
| 7 | Moderna Inc | 1.41% | 0.43% | 0.43% |
| 8 | Incyte Corp | 1.00% | 0.33% | 0.33% |
Only in XBI
148 total- Apogee Therapeutics Inc 1.49%
- Twist Bioscience Corp 1.41%
- Oruka Therapeutics Inc 1.38%
- Kymera Therapeutics Inc 1.36%
- Viking Therapeutics Inc 1.30%
- Praxis Precision Medicines Inc 1.29%
- Erasca Inc 1.27%
- Revolution Medicines Inc 1.20%
- Rhythm Pharmaceuticals Inc 1.20%
- CG oncology Inc 1.20%
Only in XLV
52 total- Eli Lilly & Co 16.51%
- Johnson & Johnson 10.64%
- UnitedHealth Group Inc 6.57%
- Merck & Co Inc 5.52%
- Thermo Fisher Scientific Inc 3.24%
- Abbott Laboratories 2.75%
- Intuitive Surgical Inc 2.45%
- Pfizer Inc 2.39%
- CVS Health Corp 2.30%
- Danaher Corp 2.09%
Related comparisons
More comparisons with XBI
- XBI vs IXJ · iShares Global Healthcare ETF 5.8%
- XBI vs IHF · iShares U.S. Healthcare Providers ETF 0.0%
- XBI vs IHI · iShares U.S. Medical Devices ETF 0.0%
- XBI vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
- XBI vs XLK · State Street Technology Select Sector SPDR ETF 0.0%
- XBI vs IBB · iShares Biotechnology ETF 41.6%
More comparisons with XLV
- XLV vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
- XLV vs XLK · State Street Technology Select Sector SPDR ETF 0.0%
- XLV vs VHT · Vanguard Health Care Index Fund ETF Shares 85.4%
- XLV vs FHLC · Fidelity MSCI Health Care Index ETF 85.0%
- XLV vs IXJ · iShares Global Healthcare ETF 70.9%
- XLV vs IHF · iShares U.S. Healthcare Providers ETF 15.5%
Percentages are holdings overlap with the named fund.
Open XBI or XLV at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.