ETF comparison
XBI vs XLV
Both Healthcare.
State Street SPDR S&P Biotech ETF · State Street Health Care Select Sector SPDR ETF
Holdings overlap
9 positions appear in both funds. Buying equal dollars of XBI and XLV would leave roughly 6.5% of each dollar exposed to the same underlying securities.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
XLV is 27 bps cheaper than XBI. On a $100,000 position that's about $270/yr more in fees for XBI.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with XBI vs XLV.
Top shared holdings
9 shared in total| # | Holding | In XBI | In XLV | Overlap |
|---|---|---|---|---|
| 1 | Regeneron Pharmaceuticals Inc | 1.14% | 1.47% | 1.14% |
| 2 | AbbVie Inc | 1.09% | 7.25% | 1.09% |
| 3 | Gilead Sciences Inc | 1.09% | 3.26% | 1.09% |
| 4 | Amgen Inc | 1.06% | 3.57% | 1.06% |
| 5 | Vertex Pharmaceuticals Inc | 1.03% | 2.14% | 1.03% |
| 6 | Biogen Inc | 1.10% | 0.51% | 0.51% |
| 7 | Moderna Inc | 1.03% | 0.33% | 0.33% |
| 8 | Incyte Corp | 1.13% | 0.30% | 0.30% |
| 9 | State Street Global Advisors | 0.00% | 0.01% | 0.00% |
Only in XBI
145 total- Apellis Pharmaceuticals Inc 1.83%
- Alkermes PLC 1.45%
- Madrigal Pharmaceuticals Inc 1.38%
- TG Therapeutics Inc 1.35%
- Insmed Inc 1.34%
- Scholar Rock Holding Corp 1.30%
- Apogee Therapeutics Inc 1.28%
- Protagonist Therapeutics Inc 1.24%
- Summit Therapeutics Inc 1.24%
- United Therapeutics Corp 1.24%
Only in XLV
51 total- Eli Lilly & Co 13.74%
- Johnson & Johnson 11.10%
- Merck & Co Inc 5.63%
- UnitedHealth Group Inc 4.62%
- Thermo Fisher Scientific Inc 3.48%
- Abbott Laboratories 3.37%
- Intuitive Surgical Inc 3.09%
- Pfizer Inc 3.01%
- Bristol-Myers Squibb Co 2.33%
- Danaher Corp 2.25%
Open XBI or XLV at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.