ETF comparison
IXJ vs XBI
Both Healthcare.
iShares Global Healthcare ETF · State Street SPDR S&P Biotech ETF
Holdings overlap
8 positions appear in both funds. Buying equal dollars of IXJ and XBI would leave roughly 5.8% of each dollar exposed to the same underlying securities.
Unmatched is the part of a fund's weight the other fund doesn't match: names only it holds, plus any extra weight it puts in names both funds hold.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
XBI is 3 bps cheaper than IXJ. On a $100,000 position that's about $30/yr more in fees for IXJ.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with IXJ vs XBI.
Top shared holdings
8 shared in total| # | Holding | In IXJ | In XBI | Overlap |
|---|---|---|---|---|
| 1 | VERTEX PHARMACEUTICALS INCORPORATED | 1.64% | 1.06% | 1.06% |
| 2 | ABBVIE INC. | 5.12% | 1.04% | 1.04% |
| 3 | AMGEN INC. | 2.54% | 0.99% | 0.99% |
| 4 | GILEAD SCIENCES, INC. | 2.04% | 0.96% | 0.96% |
| 5 | REGENERON PHARMACEUTICALS, INC. | 0.81% | 0.96% | 0.81% |
| 6 | BIOGEN INC. | 0.41% | 1.03% | 0.41% |
| 7 | MODERNA, INC. | 0.32% | 1.41% | 0.32% |
| 8 | INCYTE CORPORATION | 0.25% | 1.00% | 0.25% |
Only in IXJ
102 total- ELI LILLY AND COMPANY 10.93%
- JOHNSON & JOHNSON 7.04%
- UNITEDHEALTH GROUP INCORPORATED 4.40%
- MERCK & CO., INC. 4.12%
- ASTRAZENECA PLC 3.76%
- Roche Holding AG 3.75%
- Novartis AG 3.71%
- THERMO FISHER SCIENTIFIC INCORPORATED 2.42%
- ABBOTT LABORATORIES 2.05%
- NOVO NORDISK A/S 1.99%
Only in XBI
148 total- Apogee Therapeutics Inc 1.49%
- Twist Bioscience Corp 1.41%
- Oruka Therapeutics Inc 1.38%
- Kymera Therapeutics Inc 1.36%
- Viking Therapeutics Inc 1.30%
- Praxis Precision Medicines Inc 1.29%
- Erasca Inc 1.27%
- Revolution Medicines Inc 1.20%
- Rhythm Pharmaceuticals Inc 1.20%
- CG oncology Inc 1.20%
Related comparisons
More comparisons with IXJ
- IXJ vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
- IXJ vs XLK · State Street Technology Select Sector SPDR ETF 0.0%
- IXJ vs XLV · State Street Health Care Select Sector SPDR ETF 70.9%
- IXJ vs FHLC · Fidelity MSCI Health Care Index ETF 70.9%
- IXJ vs VHT · Vanguard Health Care Index Fund ETF Shares 70.8%
- IXJ vs IHF · iShares U.S. Healthcare Providers ETF 11.1%
More comparisons with XBI
- XBI vs IHF · iShares U.S. Healthcare Providers ETF 0.0%
- XBI vs IHI · iShares U.S. Medical Devices ETF 0.0%
- XBI vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
- XBI vs XLK · State Street Technology Select Sector SPDR ETF 0.0%
- XBI vs IBB · iShares Biotechnology ETF 41.6%
- XBI vs VHT · Vanguard Health Care Index Fund ETF Shares 12.9%
Percentages are holdings overlap with the named fund.
Open IXJ or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.