XBI
HealthcareState Street SPDR S&P Biotech ETF
State Street · Tracks S&P Biotechnology Select Industry Index · Inception Jan 31, 2006
Trailing returns
through Oct 23, 2026- 1 year
- +35.1%
- 3 year
- +32.1%
- annualized
- 5 year
- +4.1%
- annualized
Price return from month-end closes, distributions reinvested at month end. Excludes trading costs, bid-ask spreads and taxes. Past performance says nothing about future returns and is not part of the composite score — see the methodology for what the score does measure.
Composite score
Based on a 0.35% expense ratio.
Based on $10.36B in net assets.
Top-10 holdings represent 13.3% of net assets.
Healthcare base · ETF wrapper · 0.36% TTM yield.
The composite is a weighted average of the four core sub-scores above (cost, tax efficiency, liquidity, concentration). Missing sub-scores fall back to the per-category median when the category has at least 50% data coverage, so funds without (e.g.) parsed N-PORT holdings aren't accidentally boosted by renormalization. Tracking quality is shown where computable but isn't currently part of the composite weighting. See methodology for formulas, the tracking-quality partial-coverage rationale, and the dimensions we deliberately don't score (methodology v0.5.2).
Look through XBI, or compare the fee
Tool · Look-through
Underlying holdings, with other funds added
Add tickers and weights; N-PORT positions are summed across the basket.
Tool · Cost
Compare XBI's fee against another fund
Compounds the 0.35% expense ratio against a peer over decades.
Tool · Overlap
Compare XBI's holdings with peers
Pairwise holdings heatmap, pre-loaded with similar Healthcare funds.
Tool · TLH
Find a tax-loss harvesting partner for XBI
Ranks every catalog fund by holdings overlap, flags wash-sale risk.
Tool · Placement
Asset location for XBI across account types
Asset-location optimizer — places each fund in taxable / tax-deferred / Roth.
Top holdings
| # | Holding | Weight |
|---|---|---|
| 1 | Apogee Therapeutics Inc | 1.49% |
| 2 | Moderna Inc | 1.41% |
| 3 | Twist Bioscience Corp | 1.41% |
| 4 | Oruka Therapeutics Inc | 1.38% |
| 5 | Kymera Therapeutics Inc | 1.36% |
| 6 | Viking Therapeutics Inc | 1.30% |
| 7 | Praxis Precision Medicines Inc | 1.29% |
| 8 | Erasca Inc | 1.27% |
| 9 | Revolution Medicines Inc | 1.20% |
| 10 | Rhythm Pharmaceuticals Inc | 1.20% |
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