ETF comparison
IBB vs XBI
Both Healthcare.
iShares Biotechnology ETF · State Street SPDR S&P Biotech ETF
Holdings overlap
123 positions appear in both funds. Buying equal dollars of IBB and XBI would leave roughly 41.6% of each dollar exposed to the same underlying securities.
Unmatched is the part of a fund's weight the other fund doesn't match: names only it holds, plus any extra weight it puts in names both funds hold.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
XBI is 9 bps cheaper than IBB. On a $100,000 position that's about $90/yr more in fees for IBB.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with IBB vs XBI.
Top shared holdings
123 shared in total| # | Holding | In IBB | In XBI | Overlap |
|---|---|---|---|---|
| 1 | Moderna, Inc. | 1.98% | 1.41% | 1.41% |
| 2 | Revolution Medicines, Inc. | 2.78% | 1.20% | 1.20% |
| 3 | Natera, Inc. | 2.89% | 1.16% | 1.16% |
| 4 | Roivant Sciences Ltd. | 1.43% | 1.16% | 1.16% |
| 5 | Insmed, Inc. | 1.78% | 1.08% | 1.08% |
| 6 | Vertex Pharmaceuticals, Inc. | 8.08% | 1.06% | 1.06% |
| 7 | Biogen, Inc. | 2.47% | 1.03% | 1.03% |
| 8 | Ionis Pharmaceuticals, Inc. | 1.00% | 1.00% | 1.00% |
| 9 | Incyte Corp. | 1.75% | 1.00% | 1.00% |
| 10 | Amgen, Inc. | 7.83% | 0.99% | 0.99% |
| 11 | Bridgebio Pharma, Inc. | 0.98% | 1.02% | 0.98% |
| 12 | Neurocrine Biosciences, Inc. | 1.30% | 0.97% | 0.97% |
Only in IBB
125 total- Argenx SE 3.76%
- Illumina, Inc. 2.07%
- BeOne Medicines Ltd. 1.77%
- Ascendis Pharma A/S 1.29%
- Genmab A/S 1.12%
- Medpace Holdings, Inc. 0.95%
- Bio-Techne Corp. 0.86%
- Charles River Laboratories International, Inc. 0.84%
- Axsome Therapeutics, Inc. 0.82%
- Abivax SA 0.67%
Only in XBI
33 total- Viking Therapeutics Inc 1.30%
- SELLAS Life Sciences Group Inc 1.19%
- Dianthus Therapeutics Inc 1.18%
- Celcuity Inc 1.10%
- TG Therapeutics Inc 1.09%
- AbbVie Inc 1.04%
- Catalyst Pharmaceuticals Inc 0.87%
- Celldex Therapeutics Inc 0.70%
- Viridian Therapeutics Inc 0.67%
- Immunome Inc 0.59%
Related comparisons
More comparisons with IBB
- IBB vs VHT · Vanguard Health Care Index Fund ETF Shares 17.6%
- IBB vs FHLC · Fidelity MSCI Health Care Index ETF 17.6%
- IBB vs XLV · State Street Health Care Select Sector SPDR ETF 11.1%
- IBB vs IXJ · iShares Global Healthcare ETF 8.3%
- IBB vs IHF · iShares U.S. Healthcare Providers ETF 0.1%
- IBB vs IHI · iShares U.S. Medical Devices ETF 0.1%
More comparisons with XBI
- XBI vs VHT · Vanguard Health Care Index Fund ETF Shares 12.9%
- XBI vs FHLC · Fidelity MSCI Health Care Index ETF 12.6%
- XBI vs XLV · State Street Health Care Select Sector SPDR ETF 6.3%
- XBI vs IXJ · iShares Global Healthcare ETF 5.8%
- XBI vs IHF · iShares U.S. Healthcare Providers ETF 0.0%
- XBI vs IHI · iShares U.S. Medical Devices ETF 0.0%
Percentages are holdings overlap with the named fund.
Open IBB or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.