ETF comparison
VHT vs XBI
Both Healthcare.
Vanguard Health Care Index Fund ETF Shares · State Street SPDR S&P Biotech ETF
Holdings overlap
125 positions appear in both funds. Buying equal dollars of VHT and XBI would leave roughly 12.9% of each dollar exposed to the same underlying securities.
Unmatched is the part of a fund's weight the other fund doesn't match: names only it holds, plus any extra weight it puts in names both funds hold.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
VHT is 26 bps cheaper than XBI. On a $100,000 position that's about $260/yr more in fees for XBI.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with VHT vs XBI.
Top shared holdings
125 shared in total| # | Holding | In VHT | In XBI | Overlap |
|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals Inc | 1.80% | 1.06% | 1.06% |
| 2 | AbbVie Inc | 6.09% | 1.04% | 1.04% |
| 3 | Amgen Inc | 2.87% | 0.99% | 0.99% |
| 4 | Gilead Sciences Inc | 2.64% | 0.96% | 0.96% |
| 5 | Regeneron Pharmaceuticals Inc | 1.00% | 0.96% | 0.96% |
| 6 | Alnylam Pharmaceuticals Inc | 0.63% | 0.96% | 0.63% |
| 7 | Natera Inc | 0.46% | 1.16% | 0.46% |
| 8 | Biogen Inc | 0.45% | 1.03% | 0.45% |
| 9 | REVOLUTION Medicines Inc | 0.40% | 1.20% | 0.40% |
| 10 | Insmed Inc | 0.36% | 1.08% | 0.36% |
| 11 | United Therapeutics Corp | 0.36% | 0.92% | 0.36% |
| 12 | Incyte Corp | 0.26% | 1.00% | 0.26% |
Only in VHT
273 total- Eli Lilly & Co 14.04%
- Johnson & Johnson 8.47%
- UnitedHealth Group Inc 5.45%
- Merck & Co Inc 4.66%
- Thermo Fisher Scientific Inc 2.93%
- Intuitive Surgical Inc 2.38%
- Pfizer Inc 2.35%
- Abbott Laboratories 2.35%
- Bristol-Myers Squibb Co 1.84%
- Danaher Corp 1.84%
Only in XBI
31 total- SELLAS Life Sciences Group Inc 1.19%
- uniQure NV 1.03%
- CRISPR Therapeutics AG 1.02%
- Absci Corp 0.56%
- Capricor Therapeutics Inc 0.49%
- Hyperliquid Strategies Inc 0.46%
- Inhibrx Biosciences Inc 0.35%
- Avalo Therapeutics Inc 0.35%
- Jade Biosciences Inc 0.32%
- Vor BioPharma Inc 0.30%
Related comparisons
More comparisons with VHT
- VHT vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
- VHT vs XLK · State Street Technology Select Sector SPDR ETF 0.0%
- VHT vs FHLC · Fidelity MSCI Health Care Index ETF 95.2%
- VHT vs XLV · State Street Health Care Select Sector SPDR ETF 85.4%
- VHT vs IXJ · iShares Global Healthcare ETF 70.8%
- VHT vs IBB · iShares Biotechnology ETF 17.6%
More comparisons with XBI
- XBI vs FHLC · Fidelity MSCI Health Care Index ETF 12.6%
- XBI vs XLV · State Street Health Care Select Sector SPDR ETF 6.3%
- XBI vs IXJ · iShares Global Healthcare ETF 5.8%
- XBI vs IHF · iShares U.S. Healthcare Providers ETF 0.0%
- XBI vs IHI · iShares U.S. Medical Devices ETF 0.0%
- XBI vs VGT · Vanguard Information Technology Index Fund ETF Shares 0.0%
Percentages are holdings overlap with the named fund.
Open VHT or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.